Welcome to ProbeChem!Global Supplier of Chemical Probes, Inhibitors & Agonists.

You are here:Home-Chemical Inhibitors & Agonists-Apoptosis-Bcl-2-BM-957
BM-957

Chemical Structure : BM-957

CAS No.: 1391107-54-2

BM-957 (BM957)

Catalog No.: PC-61991Not For Human Use, Lab Use Only.

BM-957 (BM957) is a highly potent, dual Bcl-2 and Bcl-xL inhibitor with Ki of <1 nM for both, IC50 of 5.4 and 6.0 nM, respectively.

Packing Price Stock Quantity
25 mg Get quote
50 mg Get quote
100 mg Get quote

Bulk size, bulk discount!

Welcome credit card payment!

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    BM-957 (BM957) is a highly potent, dual Bcl-2 and Bcl-xL inhibitor with Ki of <1 nM for both, IC50 of 5.4 and 6.0 nM, respectively.
    BM-957 shows potent cell growth inhibition in cancer cell lines, with IC50 of ~20 nM against the H1147 and H146 cells.
    BM-957 induces robust cleavage of PARP and caspase-3 at 10 nM in the H146 cell line, achieves complete and durable tumor regression in H146 xenograft tumors.

    Physicochemical Properties

    M.Wt 1065.68
    Formula C52H56ClF3N6O7S3
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO

    Chemical Name/SMILES

    (R)-5-(4-Chlorophenyl)-1-ethyl-4-(3-(4-(4-(4-(4-(4-hydroxypiperidin-1-yl)-1-(phenylthio) butan-2-ylamino)-3-(trifluoromethylsulfonyl)phenylsulfonamido)phenyl)piperazin-1-yl) phenyl)-2-methyl-1H-pyrrole-3-carboxylic Acid

    References

    1. Chen J, et al. J Med Chem. 2012 Oct 11;55(19):8502-14.

    Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright

    Contact Us sales@probechem.com

    Bulk Inquiry

    * Indicates a Required FieldYour information is safe with us.

    • *Product name:
    • *Applicant name:
    • *Email address:
    • *Organization name:
    • *Requested quantity:
    • *Country:
    • *Additional Information:

    Get Quote

    * Indicates a Required FieldYour information is safe with us.

    • *Product name:
    • *Applicant name:
    • *Email address:
    • *Organization name:
    • *Requested quantity:
    • *Country:
    • Additional Information: