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Chemical Structure : BM-957
Catalog No.: PC-61991Not For Human Use, Lab Use Only.
BM-957 (BM957) is a highly potent, dual Bcl-2 and Bcl-xL inhibitor with Ki of <1 nM for both, IC50 of 5.4 and 6.0 nM, respectively.
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BM-957 (BM957) is a highly potent, dual Bcl-2 and Bcl-xL inhibitor with Ki of <1 nM for both, IC50 of 5.4 and 6.0 nM, respectively.
BM-957 shows potent cell growth inhibition in cancer cell lines, with IC50 of ~20 nM against the H1147 and H146 cells.
BM-957 induces robust cleavage of PARP and caspase-3 at 10 nM in the H146 cell line, achieves complete and durable tumor regression in H146 xenograft tumors.
| M.Wt | 1065.68 | |
| Formula | C52H56ClF3N6O7S3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Chen J, et al. J Med Chem. 2012 Oct 11;55(19):8502-14.
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