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Chemical Structure : BM001
Catalog No.: PC-49233Not For Human Use, Lab Use Only.
BM001 (BM-001) is a small molecular inhibitor of the integral growth hormone/insulin‐like growth factor‐1 (GH/IGF1) axis, shows potent antiproliferative effect on cancer cells MDA-MM-231 and Colo-205 with IC50 of 20-30 nM.
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BM001 (BM-001) is a small molecular inhibitor of the integral growth hormone/insulin‐like growth factor‐1 (GH/IGF1) axis, shows potent antiproliferative effect on cancer cells MDA-MM-231 and Colo-205 with IC50 of 20-30 nM.
BM001 (0.1-1 uM) effectively inhibits the synthesis of fos-GHRct in vitro translation experiments.
BM001 shows potential to inhibit GH-driven cancer growth and anti-cancer drug resistance.
BM001 (1-5 mg/kg) inhibited tumor growth on breast cancer growth in mice, reduced serum IGF1 levels with no effect on body weights.
| M.Wt | 334.346 | |
| Formula | C17H17F3N4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Lieke M van der Velden, et al. Front Endocrinol (Lausanne). 2022 Jul 28;13:926210.
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