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BMS-1001 hydrochloride

Chemical Structure : BMS-1001 hydrochloride

CAS No.: 2113650-04-5

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BMS-1001 hydrochloride (BMS 1001 HCl, BMS1001 HCl)

Catalog No.: PC-70035Not For Human Use, Lab Use Only.

BMS-1001 hydrochloride is a potent PD-1/PD-L1 interaction inhibitor with IC50 of 2.25 nM in a homogenous time-resolved fluorescence binding assay.

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5 mg $138 In stock
10 mg $218 In stock
25 mg $378 In stock
50 mg $588 In stock
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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

BMS-1001 hydrochloride is a potent PD-1/PD-L1 interaction inhibitor with IC50 of 2.25 nM in a homogenous time-resolved fluorescence binding assay.

Physicochemical Properties

M.Wt 667.099
Formula C35H35ClN2O7HCl
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO (6.67 mg/mL)
Chemical Name/SMILES

(2-((3-cyanobenzyl)oxy)-4-((3-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-2-methylbenzyl)oxy)-5-methylbenzyl)-D-serine hydrochloride

References

1. Guzik K, et al. J Med Chem. 2017 Jul 13;60(13):5857-5867.

2. Chupak, L.S., and Zheng, X. Compounds useful as immunomodulators. PCT/US2014/053695, (2015).

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