BMS-1166 hydrochloride | PD-1/PD-L1 inhibitor

Chemical Structure : BMS-1166 hydrochloride

Catalog No.: PC-70037Not For Human Use, Lab Use Only.

BMS-1166 hydrochloride is a potent PD-1/PD-L1 interaction inhibitor with IC50 of 1.4 nM in a homogenous time-resolved fluorescence binding assay.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

BMS-1166 hydrochloride is a potent PD-1/PD-L1 interaction inhibitor with IC50 of 1.4 nM in a homogenous time-resolved fluorescence binding assay.

M.Wt	677.094
Formula	C36H33ClN2O7HCl
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(2R,4R)-1-(5-chloro-2-((3-cyanobenzyl)oxy)-4-((3-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-2-methylbenzyl)oxy)benzyl)-4-hydroxypyrrolidine-2-carboxylic acid hydrochloride

1. Guzik K, et al. J Med Chem. 2017 Jul 13;60(13):5857-5867.

2. Chupak, L.S., and Zheng, X. Compounds useful as immunomodulators. PCT/US2014/053695, (2015).