Chemical Structure : BMS-135
CAS No.:
1541248-36-5
BMS-135
(BMS135)
Catalog No.: PC-26003Not For Human Use, Lab Use Only.
BMS-135 is a potent, ATP-competitive inhibitor of Casein kinase 2 (CK2), exhibits subnanomolar potency against both CK2α and CK2α′ isoforms with IC50 of 0.8 nM and 0.3 nM, respectively.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
BMS-135 is a potent, ATP-competitive inhibitor of Casein kinase 2 (CK2), exhibits subnanomolar potency against both CK2α and CK2α′ isoforms with IC50 of 0.8 nM and 0.3 nM, respectively.
BMS-135 demonstrated robust antiproliferative activity, with an IC50 of 8 nM in SNU-C1 colon cancer cells.
BMS-135 (15 mg/kg, twice daily) demonstrated marked antitumor efficacy in SNU-C1 colon carcinoma xenograft model.
BMS-135 also demonstrated broad-spectrum antitumor efficacy across multiple lung cancer xenograft and patient-derived xenograft (PDX) models.
Physicochemical Properties
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M.Wt
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510.94
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Formula
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C22H23ClN10O3
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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methyl ((3R,4R)-1-(2-chloro-5-cyano-3-((7-cyano-4-(ethylamino)imidazo[2,1-f][1,2,4]triazin-2-yl)amino)phenyl)-3-hydroxypiperidin-4-yl)carbamate
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References
1. A M Subbaiah M, et al. J Med Chem. 2026 Jan 22;69(2):1641-1660.
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