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BMS-159

Chemical Structure : BMS-159

CAS No.: 1541248-45-6

BMS-159 (BMS159)

Catalog No.: PC-26004Not For Human Use, Lab Use Only.

BMS-159 is the orally bioavailabile phosphate prodrug of BMS-135, which is a potent, ATP-competitive inhibitor of Casein kinase 2 (CK2), exhibits subnanomolar potency against both CK2α and CK2α′ isoforms with IC50 of 0.8 nM and 0.3 nM, respectively.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

BMS-159 is the orally bioavailabile phosphate prodrug of BMS-135, which is a potent, ATP-competitive inhibitor of Casein kinase 2 (CK2), exhibits subnanomolar potency against both CK2α and CK2α′ isoforms with IC50 of 0.8 nM and 0.3 nM, respectively.

Physicochemical Properties

M.Wt 590.92
Formula C22H24ClN10O6P
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

methyl ((3R,4R)-1-(2-chloro-5-cyano-3-((7-cyano-4-(ethylamino)imidazo[2,1-f][1,2,4]triazin-2-yl)amino)phenyl)-3-(phosphonooxy)piperidin-4-yl)carbamate

References

1. A M Subbaiah M, et al. J Med Chem. 2026 Jan 22;69(2):1641-1660.

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