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Chemical Structure : BMS-299897
CAS No.: 290315-45-6
Catalog No.: PC-45889Not For Human Use, Lab Use Only.
A potent γ-secretase inhibitor that preferentially inhibits cleavage of the APP CTF cleavage with IC50 of 7.1 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 50 mg | $284.8 | In stock |
Bulk size, bulk discount!
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A potent γ-secretase inhibitor that preferentially inhibits cleavage of the APP CTF cleavage with IC50 of 7.1 nM; 15-fold lower IC50 value for Notch-1 cleavage (IC50=105.9 nM) in vitro; alleviates Aβ1-42 seeding and short-term memory deficits in the Aβ25-35 mouse model of Alzheimer's disease.
Alzheimer's Disease
Discontinued
| M.Wt | 511.941 | |
| Formula | C24H21ClF3NO4S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: ≥ 30 mg/mL |
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| Chemical Name/SMILES |
Benzenebutanoic acid, 2-[(1R)-1-[[(4-chlorophenyl)sulfonyl](2,5-difluorophenyl)amino]ethyl]-5-fluoro- |
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1. Barten DM, et al. J Pharmacol Exp Ther. 2005 Feb;312(2):635-43.
2. Meunier J, et al. Eur J Pharmacol. 2013 Jan 5;698(1-3):193-9.
3. Goldstein ME, et al. J Pharmacol Exp Ther. 2007 Oct;323(1):102-8.
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