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Chemical Structure : BMS-309403
CAS No.: 300657-03-8
Catalog No.: PC-42435Not For Human Use, Lab Use Only.
BMS-309403 is a potent, selective, cell-permeable and orally active inhibitor of FABP4 (Fatty acid binding protein 4) with Ki of < 2 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $68 | In stock | |
| 10 mg | $98 | In stock | |
| 25 mg | $148 | In stock | |
| 50 mg | $228 | In stock | |
| 100 mg | Get quote |
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BMS-309403 is a potent, selective, cell-permeable and orally active inhibitor of FABP4 (Fatty acid binding protein 4) with Ki of < 2 nM.
BMS-309403 improves endothelial function, phosphorylated and total eNOS and reduces plasma triglyceride levels but does not affect endothelium-independent relaxations in mice.
BMS-309403 exhibits an effective therapeutic activity against severe atherosclerosis and type 2 diabetes in mouse models.
| M.Wt | 474.55 | |
| Formula | C31H26N2O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
100 mM in DMSO |
|
| Chemical Name/SMILES |
2-[[2'-(5-ethyl-3,4-diphenyl-1H-pyrazol-1-yl)[1,1'-biphenyl]-3-yl]oxy]-acetic acid |
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1. Furuhashi M, et al. Nature. 2007 Jun 21;447(7147):959-65.
2. Lee MY, et al. Br J Pharmacol. 2011 Apr;162(7):1564-76.
3. Sulsky R, et al. Bioorg Med Chem Lett. 2007 Jun 15;17(12):3511-5.
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