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Chemical Structure : BMS-433796
Catalog No.: PC-45890Not For Human Use, Lab Use Only.
BMS-433796 is a potent, orally active γ-secretase inhibitor with cell IC50 of 0.3 nM.
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BMS-433796 is a potent, orally active γ-secretase inhibitor with cell IC50 of 0.3 nM.
BMS-433796 exhibits Abeta lowering activity in a transgenic mouse model of Alzheimer's disease with acceptable pharmacodynamic and pharmacokinetic profile..
| M.Wt | 430.4 | |
| Formula | C21H20F2N4O4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: 10 mM |
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1. Prasad CV, et al. Bioorg Med Chem Lett. 2007 Jul 15;17(14):4006-11.
2. Goldstein ME, et al. J Pharmacol Exp Ther. 2007 Oct;323(1):102-8.
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