BMS-433796 | γ-secretase inhibitor | Probechem Biochemicals

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Chemical Structure : BMS-433796

BMS-433796 (BMS 433796)

Catalog No.: PC-45890Not For Human Use, Lab Use Only.

BMS-433796 is a potent, orally active γ-secretase inhibitor with cell IC50 of 0.3 nM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

BMS-433796 is a potent, orally active γ-secretase inhibitor with cell IC50 of 0.3 nM.
BMS-433796 exhibits Abeta lowering activity in a transgenic mouse model of Alzheimer's disease with acceptable pharmacodynamic and pharmacokinetic profile..

Physicochemical Properties

M.Wt	430.4
Formula	C21H20F2N4O4
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
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Solubility	DMSO: 10 mM
Chemical Name/SMILES	Benzeneacetamide, N-[(1S)-2-[[(5S)-4,5-dihydro-3-methyl-4-oxo-3H-2,3-benzodiazepin-5-yl]amino]-1-methyl-2-oxoethyl]-3,5-difluoro-α-hydroxy-, (αS)-

References

1. Prasad CV, et al. Bioorg Med Chem Lett. 2007 Jul 15;17(14):4006-11.

2. Goldstein ME, et al. J Pharmacol Exp Ther. 2007 Oct;323(1):102-8.

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BMS-433796 (BMS 433796)

Biological Activity

Physicochemical Properties

References

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