Chemical Structure : BMS-433796
Catalog No.: PC-45890Not For Human Use, Lab Use Only.
A potent, orally active γ-secretase inhibitor with cell IC50 of 0.3 nM.
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A potent, orally active γ-secretase inhibitor with cell IC50 of 0.3 nM; exhibits Abeta lowering activity in a transgenic mouse model of Alzheimer's disease with acceptable pharmacodynamic and pharmacokinetic profile..
Alzheimer's Disease
Discontinued
M.Wt | 430.4 | |
Formula | C21H20F2N4O4 | |
Appearance | Solid | |
Storage |
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Solubility |
DMSO |
1. Prasad CV, et al. Bioorg Med Chem Lett. 2007 Jul 15;17(14):4006-11.
2. Goldstein ME, et al. J Pharmacol Exp Ther. 2007 Oct;323(1):102-8.
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