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Chemical Structure : BMS-509744
CAS No.: 439575-02-7
Catalog No.: PC-42806Not For Human Use, Lab Use Only.
BMS-509744 is a potent, selective, ATP-competitive IL2--inducible T cell kinase (ITK) inhibitor with IC50 of 19 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $98 | In stock | |
| 10 mg | $158 | In stock | |
| 25 mg | $288 | In stock | |
| 50 mg | $498 | In stock | |
| 100 mg | Get quote |
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BMS-509744 is a potent, selective, ATP-competitive IL2--inducible T cell kinase (ITK) inhibitor with IC50 of 19 nM.
BMS-509744 displays >200-fold selectivity over others Tec family tyrosine kinases and > 30-fold over a broad panel protein kinases.
BMS-509744 reduces TCR-induced functions including PLCγ1 tyrosine phosphorylation, calcium mobilization, IL-2 secretion and T-cell proliferation in vitro.
BMS-509744 significantly diminishes lung inflammation in mouse model of allergy/asthma; also potently blocks wild-type HIV-1 infectivity and replication in vitro.
| M.Wt | 623.829 | |
| Formula | C32H41N5O4S2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: 21.9 mg/mL; in vivo: suspended with formulation of H2O:ethanol:Tween 80=90:5:5. |
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| Chemical Name/SMILES |
Benzamide, N-[5-[[5-[(4-acetyl-1-piperazinyl)carbonyl]-4-methoxy-2-methylphenyl]thio]-2-thiazolyl]-4-[[(1,2,2-trimethylpropyl)amino]methyl]- |
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1. Lin TA, et al. Biochemistry. 2004 Aug 31;43(34):11056-62.
2. Dondorf S, et al. J Biol Chem. 2015 Apr 17;290(16):10568-9.
3. Tarafdar S, et al. J Biol Chem. 2014 May 30;289(22):15718-28.
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