You are here:Home-Chemical Inhibitors & Agonists-Tyrosine Kinase-Insulin Receptor-BMS-536924
BMS-536924

Chemical Structure : BMS-536924

CAS No.: 468740-43-4

BMS-536924 (BMS536924, BMS 536924)

Catalog No.: PC-42501Not For Human Use, Lab Use Only.

BMS-536924 is a potent IGF-1R/InsR inhibitor with IC50 of 100 nM/73 nM, respectively.

Packing Price Stock Quantity
5 mg $88 In stock
10 mg $128 In stock
25 mg $228 In stock
50 mg $388 In stock
100 mg Get quote

Bulk size, bulk discount!

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

BMS-536924 is a potent IGF-1R/InsR inhibitor with IC50 of 100 nM/73 nM, respectively.
BMS-536924 is a weak inhibitor of CYP3A4 (IC50=0.5 uM) and potent transactivator of PXR.
BMS-536924 increases expression and activation of various members of the HER family of receptors in ovarian cancer cell lines.
BMS-536924 causes blockade of proliferation, and results in the formation of hollow polarized lumen in MCF7 cells.

Physicochemical Properties

M.Wt 479.9586
Formula C25H26ClN5O3
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

2(1H)-Pyridinone, 4-[[(2S)-2-(3-chlorophenyl)-2-hydroxyethyl]amino]-3-[7-methyl-5-(4-morpholinyl)-1H-benzimidazol-2-yl]-

References

1. Wittman M, et al. J Med Chem. 2005 Sep 8;48(18):5639-43.

2. Haluska P, et al. Mol Cancer Ther. 2008 Sep;7(9):2589-98.

3. Litzenburger BC, et al. Clin Cancer Res. 2009 Jan 1;15(1):226-37.

Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright

Contact Us sales@probechem.com

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

  • *Product name:
  • *Applicant name:
  • *Email address:
  • *Organization name:
  • *Requested quantity:
  • *Country:
  • *Additional Information:

Get Quote

* Indicates a Required FieldYour information is safe with us.

  • *Product name:
  • *Applicant name:
  • *Email address:
  • *Organization name:
  • *Requested quantity:
  • *Country:
  • Additional Information: