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Chemical Structure : BMS-536924
CAS No.: 468740-43-4
Catalog No.: PC-42501Not For Human Use, Lab Use Only.
BMS-536924 is a potent IGF-1R/InsR inhibitor with IC50 of 100 nM/73 nM, respectively.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $188 | In stock | |
| 25 mg | $298 | In stock | |
| 100 mg | Get quote | ||
| 200 mg | Get quote | ||
| 1 g | Get quote |
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BMS-536924 is a potent IGF-1R/InsR inhibitor with IC50 of 100 nM/73 nM, respectively.
BMS-536924 is a weak inhibitor of CYP3A4 (IC50=0.5 uM) and potent transactivator of PXR.
BMS-536924 increases expression and activation of various members of the HER family of receptors in ovarian cancer cell lines.
BMS-536924 causes blockade of proliferation, and results in the formation of hollow polarized lumen in MCF7 cells.
| M.Wt | 479.9586 | |
| Formula | C25H26ClN5O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
2(1H)-Pyridinone, 4-[[(2S)-2-(3-chlorophenyl)-2-hydroxyethyl]amino]-3-[7-methyl-5-(4-morpholinyl)-1H-benzimidazol-2-yl]- |
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1. Wittman M, et al. J Med Chem. 2005 Sep 8;48(18):5639-43.
2. Haluska P, et al. Mol Cancer Ther. 2008 Sep;7(9):2589-98.
3. Litzenburger BC, et al. Clin Cancer Res. 2009 Jan 1;15(1):226-37.
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