BMS-536924 is a potent IGF-1R/InsR inhibitor with IC50 of 100 nM/73 nM, respectively.
BMS-536924 is a weak inhibitor of CYP3A4 (IC50=0.5 uM) and potent transactivator of PXR.
BMS-536924 increases expression and activation of various members of the HER family of receptors in ovarian cancer cell lines.
BMS-536924 causes blockade of proliferation, and results in the formation of hollow polarized lumen in MCF7 cells.
