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Chemical Structure : BMS-595
Catalog No.: PC-35614Not For Human Use, Lab Use Only.
BMS-595 (BMS595) is a novel potent, selective, ATP-competitive casein kinase 2 (CK2) inhibitor with IC50 of 1.3 nM (CKα).
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BMS-595 (BMS595) is a novel potent, selective, ATP-competitive casein kinase 2 (CK2) inhibitor with IC50 of 1.3 nM (CKα); displays >500-fold selectivity over Auraro B, GSK-3β, PDGFRβ, and no significant activity against CDK2 and Pim1; inhibits the in vitro proliferation of human colorectal and lung cancer cell lines with an IC50 ranging from 10 nM to greater than 1 uM (EL4 cell IC50=0.208 uM); demonstrates potent antitumor effects in combination with anti-CTLA4 antibody.
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10 mM in DMSO |
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