Chemical Structure : BMS-599626
CAS No.:
714971-09-2
BMS-599626
(BMS599626;AC480;BMS 599626;AC-480;AC 480)
Catalog No. : PC-42486Not For Human Use, Lab Use Only.
BMS-599626 (AC480) is a potent, selective inhibitor of EGFR and HER2 with IC50 of 20 nM and 30 nM.
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Purity & Documentation Purity:
>98% (HPLC) Select Batch: PC-4248601
Biological Activity
BMS-599626 (AC480) is a potent, selective inhibitor of EGFR and HER2 with IC50 of 20 nM and 30 nM.
Physicochemical Properties
M.Wt
530.5535
Formula
C27H27FN8O3
Appearance
Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility
10 mM in DMSO
Chemical Name/SMILES
(S)-morpholin-3-ylmethyl (4-((1-(3-fluorobenzyl)-1H-indazol-5-yl)amino)-5-methylpyrrolo[2,1-f][1,2,4]triazin-6-yl)carbamate
References
1. Gavai AV, et al. J Med Chem. 2009 Nov 12;52(21):6527-30.
2. Wong TW, et al. Clin Cancer Res. 2006 Oct 15;12(20 Pt 1):6186-93.
3. Haluska P, et al. Mol Cancer Ther. 2008 Sep;7(9):2589-98.
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