BMS-654457 |CAS:1004551-41-0 Probechem Biochemicals

Chemical Structure : BMS-654457

BMS-654457 (BMS654457)

Catalog No.: PC-63565Not For Human Use, Lab Use Only.

BMS-654457 is a potent, reversible and direct inhibitor of factor XIa (FXa) with Ki of 0.4 nM.

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Biological Activity

BMS-654457 is a potent, reversible and direct inhibitor of factor XIa (FXa) with Ki of 0.4 nM; shows high potency in the prolongation of aPTT in human and rabbit plasma (EC2X of 2.2 and 2.4 uM, respectively) without changing prothrombin time; increases bleeding time (BT), BMS-654457 is effective in the prevention of arterial thrombosis in rabbits with limited effects on BT.

Physicochemical Properties

M.Wt
Formula
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(+) 3'-(6-carbamimidoyl-4-methyl-4-phenyl-1,2,3,4-tetrahydro-quinolin-2-yl)-4-carbamoyl-5'-(3-methyl-butyrylamino)-biphenyl-2-carboxylic acid

References

1. Wong PC, et al. J Thromb Thrombolysis. 2015 Nov;40(4):416-23.

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BMS-654457 (BMS654457)

Biological Activity

Physicochemical Properties

References

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