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Chemical Structure : BMS-654457
Catalog No.: PC-63565Not For Human Use, Lab Use Only.
BMS-654457 is a potent, reversible and direct inhibitor of factor XIa (FXa) with Ki of 0.4 nM.
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BMS-654457 is a potent, reversible and direct inhibitor of factor XIa (FXa) with Ki of 0.4 nM; shows high potency in the prolongation of aPTT in human and rabbit plasma (EC2X of 2.2 and 2.4 uM, respectively) without changing prothrombin time; increases bleeding time (BT), BMS-654457 is effective in the prevention of arterial thrombosis in rabbits with limited effects on BT.
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| Appearance | Solid | |
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10 mM in DMSO |
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1. Wong PC, et al. J Thromb Thrombolysis. 2015 Nov;40(4):416-23.
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