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Chemical Structure : BMS-695735
Catalog No.: PC-62993Not For Human Use, Lab Use Only.
BMS-695735 is a potent, selective IGF-1R inhibitor with IC50 of 34 nM.
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BMS-695735 is a potent, selective IGF-1R inhibitor with IC50 of 34 nM.
BMS-695735 also inhibits IR/FAK/Lck (IC50=72/165/14 nM), and no significant activity against PKCα, PKCδ, IKK, Akt, CDK2, CYP3A4, and PXR.
BMS-695735 exhibits improved ADME properties, a low risk for drug-drug interactions, and in vivo efficacy in multiple xenograft models; orally efficacious.
| M.Wt | 512.03 | |
| Formula | C26H31ClFN7O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Velaparthi U, et al. J Med Chem. 2008 Oct 9;51(19):5897-900.
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