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Chemical Structure : BMS-708163
CAS No.: 1146699-66-2
Catalog No.: PC-45867Not For Human Use, Lab Use Only.
Avagacestat (BMS-708163) is a potent, selective and orally bioavailable inhibitor of γ-secretase with Aβ40 IC50 of 3.0 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 1 mg (Free Sample) | $18 | In stock | |
| 5 mg | $98 | In stock | |
| 10 mg | $158 | In stock | |
| 25 mg | $278 | In stock | |
| 50 mg | Get quote | ||
| 100 mg | Get quote |
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Avagacestat (BMS-708163) is a potent, selective and orally bioavailable inhibitor of γ-secretase with Aβ40 IC50 of 3.0 nM.
Avagacestat (BMS-708163) demonstrates 193-fold selectivity against Notch.
Avagacestat (BMS-708163) significantly reduced Aβ40 levels for sustained periods in brain, plasma, and cerebrospinal fluid in rats and dogs.
| M.Wt | 520.885 | |
| Formula | C20H17ClF4N4O4S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
Pentanamide, 2-[[(4-chlorophenyl)sulfonyl][[2-fluoro-4-(1,2,4-oxadiazol-3-yl)phenyl]methyl]amino]-5,5,5-trifluoro-, (2R)- |
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1. Gillman KW, et al. ACS Med Chem Lett. 2010 Mar 22;1(3):120-4.
2. Albright CF, et al. J Pharmacol Exp Ther. 2013 Mar;344(3):686-95.
3. Mitani Y, et al. J Neurosci. 2012 Feb 8;32(6):2037-50.
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