Chemical Structure : BMS-708163
CAS No.:
1146699-66-2
BMS-708163
(Avagacestat, BMS708163)
Catalog No. : PC-45867Not For Human Use, Lab Use Only.
Avagacestat (BMS-708163) is a potent, selective and orally bioavailable inhibitor of γ-secretase with Aβ40 IC50 of 3.0 nM.
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Purity & Documentation Purity:
>98% (HPLC) Select Batch: PC-4586701
Biological Activity
Avagacestat (BMS-708163) is a potent, selective and orally bioavailable inhibitor of γ-secretase with Aβ40 IC50 of 3.0 nM.
Physicochemical Properties
M.Wt
520.885
Formula
C20H17ClF4N4O4S
Appearance
Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility
10 mM in DMSO
Chemical Name/SMILES
Pentanamide, 2-[[(4-chlorophenyl)sulfonyl][[2-fluoro-4-(1,2,4-oxadiazol-3-yl)phenyl]methyl]amino]-5,5,5-trifluoro-, (2R)-
References
1. Gillman KW, et al. ACS Med Chem Lett
2. Albright CF, et al. J Pharmacol Exp Ther.
3. Mitani Y, et al. J Neurosci.
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