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Chemical Structure : BMS-779788
CAS No.: 918348-67-1
Catalog No.: PC-45748Not For Human Use, Lab Use Only.
BMS-779788 (XL-652) is a potent, highly selective partial LXR agonist with Ki of 14 nM for LXRβ, shows moderate selectivity (5-fold) over LXRα (Ki=68 nM).
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $98 | In stock | |
| 25 mg | $148 | In stock | |
| 50 mg | $238 | In stock | |
| 100 mg | Get quote |
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BMS-779788 (XL-652) is a potent, highly selective partial LXR agonist with Ki of 14 nM for LXRβ, shows moderate selectivity (5-fold) over LXRα (Ki=68 nM).
BMS-779788 only has activity for PXR (ECU0=2 uM) in a panel of 14 NHRs.
BMS-779788 induces LXR target genes in blood in vivo (EC50=610 nM).
BMS-779788 increases in biliary cholesterol and decreases in phospholipid and bile acid in animal models.
| M.Wt | 509.0594 | |
| Formula | C28H29ClN2O3S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: ≥ 31 mg/mL |
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| Chemical Name/SMILES |
1H-Imidazole-4-methanol, 2-[1-(2-chlorophenyl)-1-methylethyl]-α,α-dimethyl-1-[3'-(methylsulfonyl)[1,1'-biphenyl]-4-yl]- |
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1. Kick E, et al. Bioorg Med Chem Lett. 2015 Jan 15;25(2):372-7.
2. Kirchgessner TG, et al. J Pharmacol Exp Ther. 2015 Feb;352(2):305-14.
3. Adams ML, et al. J Pharm Sci. 2016 Apr;105(4):1478-88.
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