Catalog No.: PC-45748Not For Human Use, Lab Use Only.
BMS-779788 (XL-652) is a potent, highly selective partial LXR agonist with Ki of 14 nM for LXRβ, shows moderate selectivity (5-fold) over LXRα (Ki=68 nM).
BMS-779788 (XL-652) is a potent, highly selective partial LXR agonist with Ki of 14 nM for LXRβ, shows moderate selectivity (5-fold) over LXRα (Ki=68 nM).
BMS-779788 only has activity for PXR (ECU0=2 uM) in a panel of 14 NHRs.
BMS-779788 induces LXR target genes in blood in vivo (EC50=610 nM).
BMS-779788 increases in biliary cholesterol and decreases in phospholipid and bile acid in animal models.
