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BMS-795311

Chemical Structure : BMS-795311

CAS No.: 939390-99-5

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BMS-795311 (BMS795311)

Catalog No.: PC-63563Not For Human Use, Lab Use Only.

BMS-795311 is a potent and orally available CETP inhibitor with IC50 of 3.8 nM, inhibits cholesteryl ester (CE) transfer with IC50 of 0.22 uM.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

BMS-795311 is a potent and orally available CETP inhibitor with IC50 of 3.8 nM, inhibits cholesteryl ester (CE) transfer with IC50 of 0.22 uM.
BMS-795311 inhibits CE transfer activity at an oral dose of 1 mg/kg in human CETP/apoB-100 dual transgenic mice and increased HDL cholesterol content and size comparable to Torcetrapib in moderately-fat fed hamsters.

Physicochemical Properties

M.Wt 671.535
Formula C33H23F10NO3
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

N-[(1R)-1-(3-Cyclopropoxy-4-fluorophenyl)-1-[3-fluoro-5-(1,1,2,2-tetrafluoroethoxy)phenyl]-2-phenylethyl]-4-fluoro-3-(trifluoromethyl)benzamide

References

1. Qiao JX, et al. J Med Chem. 2015 Nov 25;58(22):9010-26.

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