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BMS-814580

Chemical Structure : BMS-814580

CAS No.: 1197420-11-3

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BMS-814580 (BMS814580)

Catalog No.: PC-61118Not For Human Use, Lab Use Only.

BMS-814580 is a highly potent, subtype-selective melanin concentrating hormone receptor 1 (MCHR1) inhibitor with Ki of 17 nM, without inhibitory activity for MCHR2 at 10 uM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    BMS-814580 is a highly potent, subtype-selective melanin concentrating hormone receptor 1 (MCHR1) inhibitor with Ki of 17 nM, without inhibitory activity for MCHR2 at 10 uM.
    BMS-814580 exhibits functional potency with Kb of 117 nM in FLIPR-based assay, with no activity for MCHR2 at 10 uM.
    BMS-814580 dose-dependently reduces body weight in a chronic diet-induced obese model.

    Physicochemical Properties

    M.Wt 504.933
    Formula C24H19ClF2N2O4S
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    6-(4-Chlorophenyl)-3-(4-((3,3-difluoro-1-hydroxycyclobutyl)methoxy)-3-methoxyphenyl)thieno[3,2-d]pyrimidin-4(3H)-one

    References

    1. Ahmad S, et al. J Med Chem. 2016 Oct 13;59(19):8848-8858.

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