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Chemical Structure : BMS-814580
Catalog No.: PC-61118Not For Human Use, Lab Use Only.
BMS-814580 is a highly potent, subtype-selective melanin concentrating hormone receptor 1 (MCHR1) inhibitor with Ki of 17 nM, without inhibitory activity for MCHR2 at 10 uM.
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BMS-814580 is a highly potent, subtype-selective melanin concentrating hormone receptor 1 (MCHR1) inhibitor with Ki of 17 nM, without inhibitory activity for MCHR2 at 10 uM.
BMS-814580 exhibits functional potency with Kb of 117 nM in FLIPR-based assay, with no activity for MCHR2 at 10 uM.
BMS-814580 dose-dependently reduces body weight in a chronic diet-induced obese model.
| M.Wt | 504.933 | |
| Formula | C24H19ClF2N2O4S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Ahmad S, et al. J Med Chem. 2016 Oct 13;59(19):8848-8858.
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