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BMS-816336

Chemical Structure : BMS-816336

CAS No.: 1009583-20-3

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BMS-816336 (BMS 816336;BMS816336)

Catalog No.: PC-60349Not For Human Use, Lab Use Only.

BMS-816336 is a novel potent, selective, orally active human 11β-HSD1 inhibitor with IC50 of 3.0 nM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    BMS-816336 is a novel potent, selective, orally active human 11β-HSD1 inhibitor with IC50 of 3.0 nM.
    BMS-816336 displays >10,000-fold selectivity over huma 11β-HSD2.
    BMS-816336 exhibits a robust acute pharmacodynamic effect in cynomolgus monkeys (ED50=0.12 mg/kg) and in DIO mice.

    Physicochemical Properties

    M.Wt 341.451
    Formula C21H27NO3
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    2-((1R,2R,3S,5R,6R)-6-hydroxy-2-phenyladamantan-2-yl)-1-(3-hydroxyazetidin-1-yl)ethan-1-one

    References

    1. Ye XY, et al. J Med Chem. 2017 Jun 22;60(12):4932-4948.

    2. Maxwell BD. J Labelled Comp Radiopharm. 2017 Jun 30;60(8):357-365.

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