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BMS-843496

Chemical Structure : BMS-843496

CAS No.: 2044975-69-9

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BMS-843496 (BMS843496)

Catalog No.: PC-61346Not For Human Use, Lab Use Only.

BMS-843496 is a potent and selective PDE10A inhibitor with binding affinity (Kd) of 0.15 nM, IC50 of 2.11 nM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    BMS-843496 is a potent and selective PDE10A inhibitor with binding affinity (Kd) of 0.15 nM, IC50 of 2.11 nM.
    BMS-843496 displays a functional selectivity of >100-fold over other PDE subtypes.
    BMS-843496 exhibits antipsychotic-like effects in CAR models.

    Physicochemical Properties

    M.Wt 403.889
    Formula C17H18ClN7OS
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    2-((4-chloro-6-((pyridin-3-ylmethyl)amino)pyrimidin-2-yl)amino)-N-ethyl-4-methylthiazole-5-carboxamide

    References

    1. Li YW, et al. Neuropharmacology. 2016 Mar;102:121-35.

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