BMS-871 |CAS:1584631-89-9 Probechem Biochemicals

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Chemical Structure : BMS-871

BMS-871 (BMS871)

Catalog No.: PC-63562Not For Human Use, Lab Use Only.

BMS-871 (BMS871) is a potent, orally active pan-Notch inhibitor with IC50 of 4/1/4/3 nM for Notch1/2/3/4, respectively.

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Biological Activity

BMS-871 (BMS871) is a potent, orally active pan-Notch inhibitor with IC50 of 4/1/4/3 nM for Notch1/2/3/4, respectively.
BMS-871 inhibits TALL-1 tumor cell proliferation with IC50 of 4 nM.
BMS-871displays robust in vivo efficacy in Notch-dependent leukemia and triple negative breast cancer xenografts.

Physicochemical Properties

M.Wt	536.555
Formula	C29H27F3N4O3
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	(2R,3R)-N1-((S)-1-methyl-2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)-3-phenyl-2-(3,3,3-trifluoropropyl)succinamide

References

1. Shan W, et al. Bioorg Med Chem Lett. 2015 May 1;25(9):1905-9.

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BMS-871 (BMS871)

Biological Activity

Physicochemical Properties

References

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