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Chemical Structure : BMS-871
Catalog No.: PC-63562Not For Human Use, Lab Use Only.
BMS-871 (BMS871) is a potent, orally active pan-Notch inhibitor with IC50 of 4/1/4/3 nM for Notch1/2/3/4, respectively.
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BMS-871 (BMS871) is a potent, orally active pan-Notch inhibitor with IC50 of 4/1/4/3 nM for Notch1/2/3/4, respectively.
BMS-871 inhibits TALL-1 tumor cell proliferation with IC50 of 4 nM.
BMS-871displays robust in vivo efficacy in Notch-dependent leukemia and triple negative breast cancer xenografts.
| M.Wt | 536.555 | |
| Formula | C29H27F3N4O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Shan W, et al. Bioorg Med Chem Lett. 2015 May 1;25(9):1905-9.
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