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Chemical Structure : BMS-903452
Catalog No.: PC-20435Not For Human Use, Lab Use Only.
BMS-903452 (BMS 903452) is a potent and selective GPR119 agonist with EC50 of 14 nM.
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BMS-903452 (BMS 903452) is a potent and selective GPR119 agonist with EC50 of 14 nM.
BMS-903452 exhibits an excellent profile in our vitro safety assays, no significant inhibition (IC50 > 40 μM) at nine different cytochrome P450 enzymes, does not activate PXR (EC50>50 μM), and exhibits no toxicity in a hepatic (HEPG2) cell line.
BMS-903452 displays high selectivity against a panel of 95 GPCRs and enzymes in a broad receptor screening panel.
BMS-903452 significantly increased active GLP-1 levels in cannulated Sprague-Dawley rat model.
BMS-903452 exhibited synergistic effect when combined with DPPIV inhibitor.
BMS-903452 is efficacious in both acute and chronic in vivo rodent models of diabetes.
| M.Wt | 513.37 | |
| Formula | C21H19Cl2FN4O4S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Wacker DA, et al. J Med Chem. 2014 Sep 25;57(18):7499-508.
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