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Chemical Structure : BMS-911172
Catalog No.: PC-20649Not For Human Use, Lab Use Only.
BMS-911172 is a potent, selective and brain penetrant adaptor protein 2-associated kinase 1 (AAK1) inhibitor with IC50 of 12 nM.
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BMS-911172 (BMS 911172) is a potent, selective and brain penetrant adaptor protein 2-associated kinase 1 (AAK1) inhibitor with IC50 of 12 nM.
BMS-911172 exhibits good overall kinase selectivity in a panel consisting of 391 kinases (Ambit/DiscoverX/Eurofins).
BMS-911172 (60 mg/kg, sc) effectively reduced μ2 phosphorylation following acute administration in C57BL6 mice.
BMS-911172 (30 mg/kg, sc) reduces phase II formalin nociceptive behaviors in rats.
BMS-911172 (60 mg/kg, sc) reduces thermal hyperalgesia and mechanical hyperalgesia in CCI rats.
| M.Wt | 339.34 | |
| Formula | C16H19F2N3O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Richard A Hartz, et al. J. Med. Chem. 2021, 64, 15, 11090–11128.
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