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BMS-911172

Chemical Structure : BMS-911172

CAS No.: 1644248-18-9

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BMS-911172 (BMS 911172)

Catalog No.: PC-20649Not For Human Use, Lab Use Only.

BMS-911172 is a potent, selective and brain penetrant adaptor protein 2-associated kinase 1 (AAK1) inhibitor with IC50 of 12 nM.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

BMS-911172 (BMS 911172) is a potent, selective and brain penetrant adaptor protein 2-associated kinase 1 (AAK1) inhibitor with IC50 of 12 nM.
BMS-911172 exhibits good overall kinase selectivity in a panel consisting of 391 kinases (Ambit/DiscoverX/Eurofins).
BMS-911172 (60 mg/kg, sc) effectively reduced μ2 phosphorylation following acute administration in C57BL6 mice.
BMS-911172 (30 mg/kg, sc) reduces phase II formalin nociceptive behaviors in rats.
BMS-911172 (60 mg/kg, sc) reduces thermal hyperalgesia and mechanical hyperalgesia in CCI rats.

Physicochemical Properties

M.Wt 339.34
Formula C16H19F2N3O3
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(R)-2-amino-N-(3-(difluoromethoxy)-4-(oxazol-5-yl)phenyl)-4-methylpentanamide

References

1. Richard A Hartz, et al. J. Med. Chem. 2021, 64, 15, 11090–11128.

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