BMS-919373 |CAS:1272353-82-8 Probechem Biochemicals

Chemical Structure : BMS-919373

CAS No.: 1272353-82-8

BMS-919373 (BMS919373)

Catalog No.: PC-62767Not For Human Use, Lab Use Only.

BMS-919373 is a potent I(Kur)/Kv1.5 channel blocker with IC50 of 50 nM, with selectivity versus hERG, Na, Ca channels and reduced the level of brain penetration.

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Biological Activity

BMS-919373 is a potent I(Kur)/Kv1.5 channel blocker with IC50 of 50 nM, with selectivity versus hERG, Na, Ca channels and reduced the level of brain penetration.
BMS-919373 shows robust anti- arrhythmia effects in rabbit and canine pharmacodynamic models and an acceptable cross-species pharmacokinetic profile.

Physicochemical Properties

M.Wt	468.535
Formula	C25H20N6O2S
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	5-(5-phenyl-4-((pyridin-2-ylmethyl)amino)quinazolin-2-yl)pyridine-3-sulfonamide

References

1. Gunaga P, et al. J Med Chem. 2017 May 11;60(9):3795-3803.

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BMS-919373 (BMS919373)

Biological Activity

Physicochemical Properties

References

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