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Chemical Structure : BMS-932481
Catalog No.: PC-36082Not For Human Use, Lab Use Only.
BMS-932481 (BMS932481) is a potent, selective, orraly active γ-secretase modulator (GSM), shows selectivity for Aβ40 and Aβ42 reduction (IC50=6.6 nM) while sparing total Aβ levels both in vitro and in vivo.
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BMS-932481 (BMS932481) is a potent, selective, orraly active γ-secretase modulator (GSM), shows selectivity for Aβ40 and Aβ42 reduction (IC50=6.6 nM) while sparing total Aβ levels both in vitro and in vivo.
BMS-932481 showed robust reductions of Aβ1–42 and Aβ1–40 in the plasma, brain, and cerebrospinal fluid of mice and rats.
Consistent with the γ-secretase modulator mechanism, increases in Aβ1–37 and Aβ1–38 were observed, with no change in the total amount of Aβ1–x produced.
| M.Wt | 445.502 | |
| Formula | C24H24FN7O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Soares HD, et al. J Pharmacol Exp Ther. 2016 Jul;358(1):138-50.
2. Toyn JH, et al. J Pharmacol Exp Ther. 2016 Jul;358(1):125-37.
3. Kenneth M. Boy, et al. ACS Med. Chem. Lett., February 17, 2019. DOI: 10.1021/acsmedchemlett.8b00541.
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