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Chemical Structure : BMS-933043
Catalog No.: PC-61591Not For Human Use, Lab Use Only.
BMS-933043 is a novel highly selective, potent α7 nAChR partial agonist with binding Ki of 3.3 and 8.1 nM for rat and human α7, respectively.
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BMS-933043 is a novel highly selective, potent α7 nAChR partial agonist with binding Ki of 3.3 and 8.1 nM for rat and human α7, respectively; displays high selectivity against other nAChR subtypes (>100-fold) and 5-HT3A receptor (>300-fold); demonstrates in vivo activity in a preclinical model of cognitive impairment, mouse novel object recognition.
Schizophrenia
Phase 1 Discontinued
| M.Wt | 325.376 | |
| Formula | C16H19N7O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. King D, et al. ACS Med Chem Lett. 2017 Feb 8;8(3):366-371.
2. Bristow LJ, et al. PLoS One. 2016 Jul 28;11(7):e0159996.
3. Weed MR, et al. PLoS One. 2017 Dec 19;12(12):e0187609.
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