BMS-933043 |CAS:1221973-93-8 Probechem Biochemicals

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Chemical Structure : BMS-933043

BMS-933043 (BMS933043)

Catalog No.: PC-61591Not For Human Use, Lab Use Only.

BMS-933043 is a novel highly selective, potent α7 nAChR partial agonist with binding Ki of 3.3 and 8.1 nM for rat and human α7, respectively.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

BMS-933043 is a novel highly selective, potent α7 nAChR partial agonist with binding Ki of 3.3 and 8.1 nM for rat and human α7, respectively; displays high selectivity against other nAChR subtypes (>100-fold) and 5-HT3A receptor (>300-fold); demonstrates in vivo activity in a preclinical model of cognitive impairment, mouse novel object recognition.

Schizophrenia

Phase 1 Discontinued

Physicochemical Properties

M.Wt	325.376
Formula	C16H19N7O
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	(2R)-N-(6-(1H-imidazol-1-yl)-4-pyrimidinyl)-4'H-spiro[4-azabicyclo[2.2.2]octane-2,5'-[1,3]oxazol]-2'-amine

References

1. King D, et al. ACS Med Chem Lett. 2017 Feb 8;8(3):366-371.

2. Bristow LJ, et al. PLoS One. 2016 Jul 28;11(7):e0159996.

3. Weed MR, et al. PLoS One. 2017 Dec 19;12(12):e0187609.

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BMS-933043 (BMS933043)

Biological Activity

Physicochemical Properties

References

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