Chemical Structure : BMS-933043
CAS No.:
1221973-93-8
BMS-933043
(BMS933043)
Catalog No.: PC-61591Not For Human Use, Lab Use Only.
BMS-933043 is a novel highly selective, potent α7 nAChR partial agonist with binding Ki of 3.3 and 8.1 nM for rat and human α7, respectively.
| Packing | Price | Stock | Quantity |
Bulk size, bulk discount!
Welcome credit card payment!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
BMS-933043 is a novel highly selective, potent α7 nAChR partial agonist with binding Ki of 3.3 and 8.1 nM for rat and human α7, respectively; displays high selectivity against other nAChR subtypes (>100-fold) and 5-HT3A receptor (>300-fold); demonstrates in vivo activity in a preclinical model of cognitive impairment, mouse novel object recognition.
Schizophrenia
Phase 1 Discontinued
Physicochemical Properties
|
M.Wt
|
325.376
|
|
Formula
|
C16H19N7O
|
|
Appearance
|
Solid
|
|
CAS No.
|
|
|
Storage
|
- Solide Powder
-
-20 °C 12 Months; 4°C 6 Months
|
- In Solvent
-
-80 °C 6 Months; -20°C 6 Months
|
|
Shipping
|
|
|
Solubility
|
10 mM in DMSO
|
|
Chemical Name/SMILES
|
(2R)-N-(6-(1H-imidazol-1-yl)-4-pyrimidinyl)-4'H-spiro[4-azabicyclo[2.2.2]octane-2,5'-[1,3]oxazol]-2'-amine
|
References
1. King D, et al. ACS Med Chem Lett. 2017 Feb 8;8(3):366-371.
2. Bristow LJ, et al. PLoS One. 2016 Jul 28;11(7):e0159996.
3. Weed MR, et al. PLoS One. 2017 Dec 19;12(12):e0187609.
Contact Us
sales@probechem.com
