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Chemical Structure : BMS-955176
CAS No.: 1392312-45-6
Catalog No.: PC-61452Not For Human Use, Lab Use Only.
BMS-955176 (GSK-3532795) is a second-generation HIV-1 maturation inhibitor that exhibits potent activity (EC50=3.9±3.4 nM) against a library (n=87) of gag/pr recombinant viruses.
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BMS-955176 (GSK-3532795) is a second-generation HIV-1 maturation inhibitor that exhibits potent activity (EC50=3.9±3.4 nM) against a library (n=87) of gag/pr recombinant viruses.
BMS-955176 exhibits median EC50 of 21 nM toward a library of subtype B clinical isolates assayed in PBMCs.
BMS-955176 inhibits HIV-1 protease cleavage at the CA/SP1 junction within Gag in VLPs and in HIV-1-infected cells, and binds reversibly and with high affinity to assembled Gag in purified HIV-1 VLPs.
BMS-955176 has a greatly improved preclinical profile compared to that of Bevirimat.
| M.Wt | 691.03 | |
| Formula | C42H62N2O4S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
Benzoic acid, 4-[17-[[2-(1,1-dioxido-4-thiomorpholinyl)ethyl]amino]-28-norlupa-2,20(29)-dien-3-yl]- |
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1. Nowicka-Sans B, et al. Antimicrob Agents Chemother. 2016 Jun 20;60(7):3956-69.
2. Regueiro-Ren A, et al. ACS Med Chem Lett. 2016 Apr 22;7(6):568-72.
3. Lin Z, et al. PLoS Pathog. 2016 Nov 28;12(11):e1005990.
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