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BMS-962212

Chemical Structure : BMS-962212

CAS No.: 1430114-34-3

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BMS-962212 (BMS962212)

Catalog No.: PC-62006Not For Human Use, Lab Use Only.

BMS-962212 is a potent, highly selective and reversible small molecule coagulation Factor XIa (FXIa) inhibitor with Ki of 0.7 nM.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

BMS-962212 is a potent, highly selective and reversible small molecule coagulation Factor XIa (FXIa) inhibitor with Ki of 0.7 nM; displays an excellent protease selectivity profile, including thrombin, Factor Xa/VIIa/IXa/XIIa, plasma or tissue kallikrein; shows excellent preclinical efficacy in thrombosis models and aqueous solubility suitable for intravenous administration.

Thrombosis

Phase 1 Clinical

Physicochemical Properties

M.Wt 659.075
Formula C32H28ClFN8O5
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(S,E)-4-(2-(3-(3-Chloro-2-fluoro-6-(1H-tetrazol-1-yl)phenyl)-acryloyl)-5-(4-methyl-2-oxopiperazin-1-yl)-1,2,3,4-tetrahydroisoquinoline-1-carboxamido)benzoic acid

References

1. Pinto DJP, et al. J Med Chem. 2017 Dec 14;60(23):9703-9723.

2. Perera V, et al. Br J Clin Pharmacol. 2018 Jan 18. doi: 10.1111/bcp.13520.

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