BMS-962212 is a potent, highly selective and reversible small molecule coagulation Factor XIa (FXIa) inhibitor with Ki of 0.7 nM.
BMS-962212 displays an excellent protease selectivity profile, including thrombin, Factor Xa/VIIa/IXa/XIIa, plasma or tissue kallikrein.
BMS-962212 shows excellent preclinical efficacy in thrombosis models and aqueous solubility suitable for intravenous administration.
