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BMS-986115

Chemical Structure : BMS-986115

CAS No.: 1584647-27-7

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BMS-986115 (BMS986115)

Catalog No.: PC-61757Not For Human Use, Lab Use Only.

BMS-986115 is an orally bioavailable, γ-secretase and pan-Notch inhibitor with potential antineoplastic activity.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    BMS-986115 is an orally bioavailable, γ-secretase and pan-Notch inhibitor with potential antineoplastic activity.
    BMS-986115 binds to gamma-secretase and blocks the proteolytic cleavage and release of the Notch intracellular domain (NICD), which would normally follow ligand binding to the extracellular domain of the Notch receptor.
    BMS-986115 induces apoptosis and inhibits growth of tumor cells that overexpress Notch.

    Physicochemical Properties

    M.Wt 574.495
    Formula C26H25F7N4O3
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    (2R,3S)-N1-[(3S)-5-(3-Fluorophenyl)-2,3-dihydro-9-methyl-2-oxo-1H-1,4-benzodiazepin-3-yl]-2,3-bis(3,3,3-trifluoropropyl)butanediamide

    References

    1. Aung KL,et al. Invest New Drugs. 2018 Dec;36(6):1026-1036.

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