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Chemical Structure : BMS-986115
Catalog No.: PC-61757Not For Human Use, Lab Use Only.
BMS-986115 is an orally bioavailable, γ-secretase and pan-Notch inhibitor with potential antineoplastic activity.
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BMS-986115 is an orally bioavailable, γ-secretase and pan-Notch inhibitor with potential antineoplastic activity.
BMS-986115 binds to gamma-secretase and blocks the proteolytic cleavage and release of the Notch intracellular domain (NICD), which would normally follow ligand binding to the extracellular domain of the Notch receptor.
BMS-986115 induces apoptosis and inhibits growth of tumor cells that overexpress Notch.
| M.Wt | 574.495 | |
| Formula | C26H25F7N4O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Aung KL,et al. Invest New Drugs. 2018 Dec;36(6):1026-1036.
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