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BMS-986118

Chemical Structure : BMS-986118

CAS No.: 1610562-74-7

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BMS-986118 (BMS986118)

Catalog No.: PC-63298Not For Human Use, Lab Use Only.

BMS-986118 is a potent and selective GPR40 agonist with EC50 of 70 and 63 nM for hGPR40 and mGPR40, shows no PPARγ activity (EC50>47 uM).

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    BMS-986118 is a potent and selective GPR40 agonist with EC50 of 70 and 63 nM for hGPR40 and mGPR40, shows no PPARγ activity (EC50>47 uM).
    BMS-986118 demonstrates insulinotropic efficacy and GLP-1 secretory effects resulting in improved glucose control in acute animal models.

    Physicochemical Properties

    M.Wt 540.968
    Formula C25H28ClF3N4O4
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    2-((4S,5S)-1-(4-(((3R,4R)-1-(5-Chloro-2-methoxypyridin-4-yl)-3-methylpiperidin-4-yl)oxy)phenyl)-4-methyl-3-(trifluoromethyl)-4,5-dihydro-1H-pyrazol-5-yl)acetic acid

    References

    1. Shi J, et al. J Med Chem. 2018 Feb 8;61(3):681-694.

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