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Chemical Structure : BMS-986118
Catalog No.: PC-63298Not For Human Use, Lab Use Only.
BMS-986118 is a potent and selective GPR40 agonist with EC50 of 70 and 63 nM for hGPR40 and mGPR40, shows no PPARγ activity (EC50>47 uM).
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BMS-986118 is a potent and selective GPR40 agonist with EC50 of 70 and 63 nM for hGPR40 and mGPR40, shows no PPARγ activity (EC50>47 uM).
BMS-986118 demonstrates insulinotropic efficacy and GLP-1 secretory effects resulting in improved glucose control in acute animal models.
| M.Wt | 540.968 | |
| Formula | C25H28ClF3N4O4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Shi J, et al. J Med Chem. 2018 Feb 8;61(3):681-694.
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