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Chemical Structure : BMS-986169
Catalog No.: PC-35166Not For Human Use, Lab Use Only.
BMS-986169 is a novel GluN2B negative allosteric modulator, demonstrates high binding affinity for the GluN2B allosteric site (Ki=4.0 nM) and selective inhibition of GluN2B receptor function (IC50=24 nM) in cells.
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BMS-986169 is a novel GluN2B negative allosteric modulator, demonstrates high binding affinity for the GluN2B allosteric site (Ki=4.0 nM) and selective inhibition of GluN2B receptor function (IC50=24 nM) in cells.
BMS-986169 shows negligible activity in an assay panel containing 40 additional pharmacological targets, and weakly inhibits hERG channel; produces a transient working memory impairment in monkeys.
BMS-986169 does not produce ketamine-like hyperlocomotion or abnormal behaviors in mice or cynomolgus monkeys.
| M.Wt | 382.479 | |
| Formula | C23H27FN2O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Marcin LR, et al. ACS Med Chem Lett. 2018 Apr 13;9(5):472-477.
2. Bristow LJ, et al. J Pharmacol Exp Ther. 2017 Dec;363(3):377-393.
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