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Chemical Structure : BMS-986205
CAS No.: 1923833-60-6
Catalog No.: PC-60068Not For Human Use, Lab Use Only.
BMS-986205 (Linrodostat, F-001287, ONO-7701) is a novel potent, selective and orally available IDO1 inhibitor with IC50 of 1.1 nM in cell-based assays.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $78 | In stock | |
| 10 mg | $118 | In stock | |
| 25 mg | $218 | In stock | |
| 50 mg | $358 | In stock | |
| 100 mg | $548 | In stock | |
| 250 mg | Get quote |
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BMS-986205 (Linrodostat, F-001287, ONO-7701) is a novel potent, selective and orally available IDO1 inhibitor with IC50 of 1.1 nM in cell-based assays.
BMS-986205 has no inhibitory activity on TDO, potently inhibits kynurenine (kyn) production in IDO1-HEK293 cells with IC50 of 1.1 nM;.
BMS-986205 shows potential with superior PD properties and support further evaluation in combination with vivo.
| M.Wt | 410.912 | |
| Formula | C24H24ClFN2O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
(2R)-N-(4-Chlorophenyl)-2-[cis-4-(6-fluoro-4-quinolinyl)cyclohexyl]propanamide |
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1. Richards T, et al. Oncotarget. 2018 Jul 20;9(56):30814-30820.
2. Lillian L. Siu, et al. AACR; Cancer Res. 2017; 77 (13 Suppl): Abstract nr CT116.
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