BMS-986235 (LAR-1219) | FPR2 agonist | Probechem Biochemicals

Chemical Structure : BMS-986235

CAS No.: 2253947-47-4

BMS-986235 (LAR-1219, BMS986235, LAR1219)

Catalog No.: PC-49033Not For Human Use, Lab Use Only.

BMS-986235 (LAR-1219) is a potent, selective, and orally bioavailable agonist of formyl peptide receptor 2 (FPR2) with EC50 of 0.4 nM (hFPR2), >7,000-fold selectivity over FPR1.

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10 mg	$248	In stock
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Biological Activity

BMS-986235 (LAR-1219) is a potent, selective, and orally bioavailable agonist of formyl peptide receptor 2 (FPR2) with EC50 of 0.4 nM (hFPR2), >7,000-fold selectivity over FPR1.
BMS-986235 produced concentration-dependent modulation of BRET signals for Gαi1, Gαi2, Gαi3, GαoA, and GαoB biosensors following FPR2 activation (EC50=5-13 nM), 164- to 614-fold selectivity over FPR1 activation.
BMS-986235 improved mouse survival, reduced left ventricular area, reduced scar area, and preserved wall thickness, inhibited neutrophil chemotaxis and stimulated macrophage phagocytosis, key end points to promote resolution of inflammation.
BMS-986235 preserved viable myocardium, attenuated left ventricular remodeling, and increased ejection fraction in rats following MI.

Physicochemical Properties

M.Wt	361.349
Formula	C18H17F2N3O3
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	1-((3S,4R)-4-(2,6-difluoro-4-methoxyphenyl)-2-oxopyrrolidin-3-yl)-3-phenylurea

References

1. Yoshikazu Asahina, et al. J Med Chem. 2020 Sep 10;63(17):9003-9019.

2. Ricardo A García, et al. JACC Basic Transl Sci. 2021 Aug 23;6(8):676-689.

BMS-986235 (LAR-1219, BMS986235, LAR1219)

Biological Activity

Physicochemical Properties

References

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