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Chemical Structure : BMS-986242
CAS No.: 1923844-48-7
Catalog No.: PC-72378Not For Human Use, Lab Use Only.
BMS-986242 (BMS986242) is a potent, selective IDO1 inhibitor with IC50 of 2 nM in cellular IDO1 inhibition assays and IC50 of 25 nM in human whole blood (HWB) IDO1 inhibition assays.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $298 | In stock | |
| 10 mg | $488 | In stock | |
| 25 mg | $758 | In stock | |
| 50 mg | Get quote | ||
| 100 mg | Get quote |
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BMS-986242 (BMS986242) is a potent, selective IDO1 inhibitor with IC50 of 2 nM in cellular IDO1 inhibition assays and IC50 of 25 nM in human whole blood (HWB) IDO1 inhibition assays.
BMS-986242 shows activity against a variety of cancers including metastatic melanoma and renal cell carcinoma.
BMS-986242 elicited a PD effect comparable to linrodostat and epacadostat in a PD model of tumor kynurenine reduction at a lower level of exposure.
BMS-986242 is a structurally differentiated clinical candidate that performs comparably to linrodostat (BMS-986205) in terms of both in vitro potency and in vivo pharmacodynamic effect in a mouse xenograft model.
| M.Wt | 410.917 | |
| Formula | C24H24ClFN2O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
4-chloro-N-((R)-1-((1s,4S)-4-(6-fluoroquinolin-4-yl)cyclohexyl)ethyl)benzamide |
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1. Cherney EC, et al. ACS Med Chem Lett. 2021 Jan 28;12(2):288-294.
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