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Chemical Structure : BMS-986308
Catalog No.: PC-22457Not For Human Use, Lab Use Only.
BMS-986308 is a potent, selective inhibitor of renal outer medullary potassium (ROMK, Kir1.1, KCNJ1) channel with IC50 of 24 nM.
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BMS-986308 is a potent, selective inhibitor of renal outer medullary potassium (ROMK, Kir1.1, KCNJ1) channel with IC50 of 24 nM.
BMS-986308 displays no inhibitory potency against related inwardly rectifying potassium channels (Kir2.1, Kir2.3, Kir4.1, and Kir7.1), as well as an internal panel of 49 GPCRs, enzymes, and ion channels.
BMS-986308 demonstrated efficacy in the volume-loaded rat diuresis model as well as promising in vitro and in vivo profiles.
| M.Wt | 443.51 | |
| Formula | C24H25N7O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Jeremy M Richter, et al. J Med Chem. 2024 Jun 13;67(11):9731-9744.
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