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BMS-986449

Chemical Structure : BMS-986449

CAS No.:

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BMS-986449 (BMS986449)

Catalog No.: PC-24664Not For Human Use, Lab Use Only.

BMS-986449 is a highly potent and selective, orally bioavailable degrader of the transcription factors Helios (IKZF2) and Eos (IKZF4).

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

BMS-986449 is a highly potent and selective, orally bioavailable degrader of the transcription factors Helios (IKZF2) and Eos (IKZF4).
BMS-986449 shows minimal impact on IKZF1/3 levels in regulatory T-cells as assessed by global proteomics.
BMS-986449 affects in vitro reprogramming of Treg cells to have a more effector-like phenotype that results in promising in vivo efficacy in syngeneic tumor models.

Physicochemical Properties

M.Wt 395.43
Formula C22H22FN3O3
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(R)-3-((2R,3S)-5-(6-amino-4,5-dimethylpyridin-2-yl)-4-fluoro-3-methyl-1-oxo-2,3-dihydro-1H-inden-2-yl)piperidine-2,6-dione

References

1. Aaron Balog. Cancer Res (2025) 85 (8_Supplement_2): ND05.

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