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Chemical Structure : BMS191095
CAS No.: 166095-21-2
Catalog No.: PC-22096Not For Human Use, Lab Use Only.
BMS191095 (BMS-191095) is a selective ATP-sensitive potassium channel (KATP) opener, exhibits antiischemic (cardioprotective) potency with EC25 of 1.4 uM.
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BMS191095 (BMS-191095) is a selective ATP-sensitive potassium channel (KATP) opener, exhibits antiischemic (cardioprotective) potency with EC25 of 1.4 uM.
BMS191095 is over 20- and 4000-fold more selective for the ischemic myocardium than BMS-180448 and cromakalim.
BMS191095 is devoid of peripheral vasodilating activity while retaining glyburide-reversible cardioprotective activity.
BMS-191095 improved postischemic recovery of function and reduced lactate dehydrogenase release in the isolated rat hearts.
BMS-191095 opened cardiac mitochondrial K(ATP) with a K(1/2) of 83 nM.
| M.Wt | 408.89 | |
| Formula | C22H21ClN4O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
(3R,4S)-4-[(4-Chlorophenyl)(1H-imidazol-2-ylmethyl)amino]-3,4-dihydro-3-hydroxy-2,2-dimethyl-2H-1-benzopyran-6-carbonitrile |
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1. Rovnyak GC, et al. J Med Chem. 1997 Jan 3;40(1):24-34.
2. Grover GJ, et al. J Pharmacol Exp Ther. 2001 Jun;297(3):1184-92.
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