Catalog No.: PC-22096Not For Human Use, Lab Use Only.
BMS191095 (BMS-191095) is a selective ATP-sensitive potassium channel (KATP) opener, exhibits antiischemic (cardioprotective) potency with EC25 of 1.4 uM.
BMS191095 (BMS-191095) is a selective ATP-sensitive potassium channel (KATP) opener, exhibits antiischemic (cardioprotective) potency with EC25 of 1.4 uM. BMS191095 is over 20- and 4000-fold more selective for the ischemic myocardium than BMS-180448 and cromakalim. BMS191095 is devoid of peripheral vasodilating activity while retaining glyburide-reversible cardioprotective activity. BMS-191095 improved postischemic recovery of function and reduced lactate dehydrogenase release in the isolated rat hearts. BMS-191095 opened cardiac mitochondrial K(ATP) with a K(1/2) of 83 nM.
