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Chemical Structure : BMS433771
Catalog No.: PC-63269Not For Human Use, Lab Use Only.
BMS433771 is a potent, orally active RSV fusion inhibitor, exhibits excellent potency against multiple laboratory and clinical isolates of both group A and B viruses with mean EC50 of 20 nM.
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BMS433771 is a potent, orally active RSV fusion inhibitor, exhibits excellent potency against multiple laboratory and clinical isolates of both group A and B viruses with mean EC50 of 20 nM; inhibits the fusion of lipid membranes during both the early virus entry stage and late-stage syncytium formation; A series of single amino acid mutations in the F1 subunit of the fusion protein confers resistance to BMS433771.
| M.Wt | 377.448 | |
| Formula | C21H23N5O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Cianci C, et al. Antimicrob Agents Chemother. 2004 Feb;48(2):413-22.
2. Cianci C, et al. Antimicrob Agents Chemother. 2004 Jul;48(7):2448-54.
3. Cianci C, et al. Proc Natl Acad Sci U S A. 2004 Oct 19;101(42):15046-51.
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