Chemical Structure : BMS433771
CAS No.:
543700-68-1
BMS433771
(BMS-433771)
Catalog No.: PC-63269Not For Human Use, Lab Use Only.
BMS433771 is a potent, orally active RSV fusion inhibitor, exhibits excellent potency against multiple laboratory and clinical isolates of both group A and B viruses with mean EC50 of 20 nM.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
BMS433771 is a potent, orally active RSV fusion inhibitor, exhibits excellent potency against multiple laboratory and clinical isolates of both group A and B viruses with mean EC50 of 20 nM; inhibits the fusion of lipid membranes during both the early virus entry stage and late-stage syncytium formation; A series of single amino acid mutations in the F1 subunit of the fusion protein confers resistance to BMS433771.
Physicochemical Properties
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M.Wt
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377.448
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Formula
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C21H23N5O2
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20 °C 12 Months; 4°C 6 Months
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- In Solvent
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-80 °C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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1-Cyclopropyl-3-[[1-(4-hydroxybutyl)benzimidazol-2-yl]methyl]imidazo[4,5-c]pyridin-2-one
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References
1. Cianci C, et al. Antimicrob Agents Chemother. 2004 Feb;48(2):413-22.
2. Cianci C, et al. Antimicrob Agents Chemother. 2004 Jul;48(7):2448-54.
3. Cianci C, et al. Proc Natl Acad Sci U S A. 2004 Oct 19;101(42):15046-51.
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