BMX-IN-1 (CAS 1431525-23-3) is a potent, selective, irreversible inhibitor of BMX kinase with IC50 of 8 nM.
BMX-IN-1 also inhibits BTK with IC50 of 10.4 nM and displays 47-656-fold less potent for Blk, JAK3, EGFR, Itk, or Tec.
BMX-IN-1 inhibits the proliferation of Tel-BMX-transformed Ba/F3 prostate cancer cells with GI50 of 25 nM, exhibits antiproliferative activity in RV-1, DU-145, PC-3, and VCAP prostate cancer cell lines with GI50 of 2-5 uM.
