Catalog No.: PC-27162Not For Human Use, Lab Use Only.
BMY-14802 hydrochloride is a potent sigma-1 receptor (σ1R) antagonist with IC50 of 112 nM, also an agonist at serotonin 5-HT1A (IC50=320 nM) and adrenergic α-1 receptor (IC50=460 nM).
BMY-14802 hydrochloride is a potent sigma-1 receptor (σ1R) antagonist with IC50 of 112 nM, also an agonist at serotonin 5-HT1A (IC50=320 nM) and adrenergic α-1 receptor (IC50=460 nM). BMY-14802 does not bind with high affinity to the D1 or D2 receptor (IC50s>1,000 and 6,430 nM, respectively). BMY-14802 suppresses not only AIM but also L-DOPA-induced rotation. The AIM-suppressing action of BMY-14802 is dependent on 5-HT1A but not adrenergic α-1 receptors, as this effect is prevented by the 5-HT1A antagonist WAY-100653 but not the α-1 antagonist prazosin.
