BNBI

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Chemical Structure : BNBI

Catalog No.: PC-60575Not For Human Use, Lab Use Only.

BNBI is a selective renal outer medullary potassium channel (ROMK, Kir1.1) inhibitor with IC50 of 8 uM in T1+ flux assays, does not inhibit Kir7.1 at 100 uM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

BNBI is a selective renal outer medullary potassium channel (ROMK, Kir1.1) inhibitor with IC50 of 8 uM in T1+ flux assays, does not inhibit Kir7.1 at 100 uM.
BNBI has no detectable effect on uterine contractility in the GD15 mouse at 100 uM.

Physicochemical Properties

M.Wt	366.337
Formula	C17H14N6O4
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	1,3-Bis(5-nitro-1H-benzo[d]imidazol-2-yl)propane

References

1. Bhave G, et al. Mol Pharmacol. 2011 Jan;79(1):42-50.

2. Lewis LM, et al. Mol Pharmacol. 2009 Nov;76(5):1094-103.

3. McCloskey C, et al. EMBO Mol Med. 2014 Sep;6(9):1161-74.

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BNBI

Biological Activity

Physicochemical Properties

References

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