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Chemical Structure : BNS-22
Catalog No.: PC-62442Not For Human Use, Lab Use Only.
BNS-22 is a small-molecule inhibitor of DNA topoisomerase II, inhibits kinetoplast DNA decatenation that is mediated by human TOP2α and TOP2β in vitro with IC50 of 2.8 and 0.42 uM, respectively.
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BNS-22 is a small-molecule inhibitor of DNA topoisomerase II, inhibits kinetoplast DNA decatenation that is mediated by human TOP2α and TOP2β in vitro with IC50 of 2.8 and 0.42 uM, respectively.
BNS-22 does not affect DNA damage and antagonizes TOP2 poison-mediated DNA damage.
BNS-22 induces mitotic abnormalities, causes polyploidy in HeLa cells.
| M.Wt | 407.466 | |
| Formula | C24H25NO5 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Kawatani M, et al. Chem Biol. 2011 Jun 24;18(6):743-51.
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