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BNS-22

Chemical Structure : BNS-22

CAS No.: 1151668-24-4‎

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BNS-22 (BNS22)

Catalog No.: PC-62442Not For Human Use, Lab Use Only.

BNS-22 is a small-molecule inhibitor of DNA topoisomerase II, inhibits kinetoplast DNA decatenation that is mediated by human TOP2α and TOP2β in vitro with IC50 of 2.8 and 0.42 uM, respectively.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    BNS-22 is a small-molecule inhibitor of DNA topoisomerase II, inhibits kinetoplast DNA decatenation that is mediated by human TOP2α and TOP2β in vitro with IC50 of 2.8 and 0.42 uM, respectively.
    BNS-22 does not affect DNA damage and antagonizes TOP2 poison-mediated DNA damage.
    BNS-22 induces mitotic abnormalities, causes polyploidy in HeLa cells.

    Physicochemical Properties

    M.Wt 407.466
    Formula C24H25NO5
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    8-[(3,4-Dihydro-2H-quinolin-1-yl)carbonyl]-5,7-dimethoxy-4-propyl-2H-chromen-2-one

    References

    1. Kawatani M, et al. Chem Biol. 2011 Jun 24;18(6):743-51.

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