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Chemical Structure : BNZ-111
Catalog No.: PC-23110Not For Human Use, Lab Use Only.
BNZ-111 is a novel reversible tubulin inhibitor, binds the β subunit of curved tubulin, possesses potent anticancer activities to various cancer cell lines.
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BNZ-111 is a novel reversible tubulin inhibitor, binds the β subunit of curved tubulin, possesses potent anticancer activities to various cancer cell lines.
BNZ-111 prevents tubulin from adapting a straight structure
BNZ-111 shows a significant tumor growth inhibition in vivo in Paclitaxel resistant HeyA8-MDR human ovarian cancer bearing mice models without significant body weight change.
BNZ-111 possesses good drug-like properties for as oral drug.
| M.Wt | 265.29 | |
| Formula | C13H16FN3O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Jiyoon Jang, et al. Bioorg Med Chem Lett. 2024 Sep 11:113:129953.
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