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BNZ-111

Chemical Structure : BNZ-111

CAS No.: 3022361-60-7

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BNZ-111 (BNZ111)

Catalog No.: PC-23110Not For Human Use, Lab Use Only.

BNZ-111 is a novel reversible tubulin inhibitor, binds the β subunit of curved tubulin, possesses potent anticancer activities to various cancer cell lines.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

BNZ-111 is a novel reversible tubulin inhibitor, binds the β subunit of curved tubulin, possesses potent anticancer activities to various cancer cell lines.
BNZ-111 prevents tubulin from adapting a straight structure
BNZ-111 shows a significant tumor growth inhibition in vivo in Paclitaxel resistant HeyA8-MDR human ovarian cancer bearing mice models without significant body weight change.
BNZ-111 possesses good drug-like properties for as oral drug.

Physicochemical Properties

M.Wt 265.29
Formula C13H16FN3O2
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

N-(5-fluoro-6-propoxy-1H-benzo[d]imidazol-2-yl)propionamide

References

1. Jiyoon Jang, et al. Bioorg Med Chem Lett. 2024 Sep 11:113:129953.

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