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Chemical Structure : BP-1-102
CAS No.: 1334493-07-0
Catalog No.: PC-42174Not For Human Use, Lab Use Only.
BP-1-102 is an orally bioavailable, small-molecule inhibitor of STAT3 with Kd of 504 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $88 | In stock | |
| 10 mg | $128 | In stock | |
| 25 mg | $198 | In stock | |
| 50 mg | $328 | In stock | |
| 100 mg | Get quote |
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BP-1-102 is an orally bioavailable, small-molecule inhibitor of STAT3 with Kd of 504 nM.
BP-1-102 blocks Stat3-pTyr peptide interactions and Stat3 activation at 4-6.8 uM, and selectively inhibits growth, survival, migration, and invasion of Stat3-dependent tumor cells.
BP-1-102 suppresses the expression of c-Myc, Cyclin D1, Bcl-xL, Survivin, VEGF, and KLF8, blocks Stat3-NF-κB cross-talk, and enhances E-cadherin expression.
BP-1-102 inhibits growth of human breast and lung tumor xenografts.
| M.Wt | 626.5915 | |
| Formula | C29H27F5N2O6S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: ≥ 33 mg/mL |
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| Chemical Name/SMILES |
Benzoic acid, 4-[[(4-cyclohexylphenyl)methyl][2-[methyl[(2,3,4,5,6-pentafluorophenyl)sulfonyl]amino]acetyl]amino]-2-hydroxy- |
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1. Zhang X, et al. Proc Natl Acad Sci U S A. 2012 Jun 12;109(24):9623-8.
2. De Simone V, et al. Oncogene. 2015 Jul;34(27):3493-503.
3. Resetca D, et al. J Biol Chem. 2014 Nov 21;289(47):32538-47.
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