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Chemical Structure : BP-1-108
Catalog No.: PC-20631Not For Human Use, Lab Use Only.
BP-1-108 is a small molecule STAT5-SH2 domain inhibitor with Ki of 2.8 uM, shows weak affinity for Stat1 and Stat3 (Ki, 9,7 and 8.0 uM respectively).
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BP-1-108 is a small molecule STAT5-SH2 domain inhibitor with Ki of 2.8 uM, shows weak affinity for Stat1 and Stat3 (Ki, 9,7 and 8.0 uM respectively).
BP-1-108 shows potent induction of apoptosis (IC50=20 μM), which correlated with potent and selective suppression of STAT5 phosphorylation, as well as inhibition of STAT5 target genes cyclin D1, cyclin D2, C-MYC, and MCL-1, in K562 and MV-4-11 human leukemia cells.
BP-1-108 shows negligible cytotoxic effects in normal bone marrow cells not expressing activated STAT5 protein.
| M.Wt | 578.72 | |
| Formula | C32H38N2O6S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Brent D G Page, et al. J Med Chem. 2012 Feb 9;55(3):1047-55.
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