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BP-1-108

Chemical Structure : BP-1-108

CAS No.: 1334492-85-1

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BP-1-108

Catalog No.: PC-20631Not For Human Use, Lab Use Only.

BP-1-108 is a small molecule STAT5-SH2 domain inhibitor with Ki of 2.8 uM, shows weak affinity for Stat1 and Stat3 (Ki, 9,7 and 8.0 uM respectively).

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    BP-1-108 is a small molecule STAT5-SH2 domain inhibitor with Ki of 2.8 uM, shows weak affinity for Stat1 and Stat3 (Ki, 9,7 and 8.0 uM respectively).
    BP-1-108 shows potent induction of apoptosis (IC50=20 μM), which correlated with potent and selective suppression of STAT5 phosphorylation, as well as inhibition of STAT5 target genes cyclin D1, cyclin D2, C-MYC, and MCL-1, in K562 and MV-4-11 human leukemia cells.
    BP-1-108 shows negligible cytotoxic effects in normal bone marrow cells not expressing activated STAT5 protein.

    Physicochemical Properties

    M.Wt 578.72
    Formula C32H38N2O6S
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    4-(N-(4-cyclohexylbenzyl)-2-((N,2,4,6-tetramethylphenyl)sulfonamido)acetamido)-2-hydroxybenzoic acid

    References

    1. Brent D G Page, et al. J Med Chem. 2012 Feb 9;55(3):1047-55.

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