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Chemical Structure : BP-5-087
Catalog No.: PC-61260Not For Human Use, Lab Use Only.
BP-5-087 is a potent, selective STAT3 SH2 domain inhibitor (EC50=5.6 uM) that reduces STAT3 phosphorylation and nuclear transactivation.
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BP-5-087 is a potent, selective STAT3 SH2 domain inhibitor (EC50=5.6 uM) that reduces STAT3 phosphorylation and nuclear transactivation.
BP-5-087 restores TKI sensitivity to therapy-resistant CML progenitor cells in primary cells from CML patients with BCR-ABL1 kinase-independent TKI resistance, including leukemic stem cells.
| M.Wt | 770.691 | |
| Formula | C36H30F8N2O6S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Eiring AM, et al. Leukemia. 2015 Mar;29(3):586-597.
2. Eiring AM, et al. Leuk Suppl. 2014 Dec;3(Suppl 1):S5-6.
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