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BP-5-087

Chemical Structure : BP-5-087

CAS No.: 1803281-30-2

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BP-5-087 (BP 5-087)

Catalog No.: PC-61260Not For Human Use, Lab Use Only.

BP-5-087 is a potent, selective STAT3 SH2 domain inhibitor (EC50=5.6 uM) that reduces STAT3 phosphorylation and nuclear transactivation.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    BP-5-087 is a potent, selective STAT3 SH2 domain inhibitor (EC50=5.6 uM) that reduces STAT3 phosphorylation and nuclear transactivation.
    BP-5-087 restores TKI sensitivity to therapy-resistant CML progenitor cells in primary cells from CML patients with BCR-ABL1 kinase-independent TKI resistance, including leukemic stem cells.

    Physicochemical Properties

    M.Wt 770.691
    Formula C36H30F8N2O6S
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    4-(N-(4-cyclohexylbenzyl)-2-((N-((perfluorophenyl)methyl)-4-(trifluoromethyl)phenyl)sulfonamido)acetamido)-2-hydroxybenzoic acid

    References

    1. Eiring AM, et al. Leukemia. 2015 Mar;29(3):586-597.

    2. Eiring AM, et al. Leuk Suppl. 2014 Dec;3(Suppl 1):S5-6.

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