Catalog No.: PC-20090Not For Human Use, Lab Use Only.
BPAM344 (BPAM-344) is a positive allosteric modulator of GluK2 kainate receptor, potentiates glutamate-evoked currents of GluK2a 21-fold at 200 uM (EC50=79 uM).
BPAM344 (BPAM-344) is a positive allosteric modulator of GluK2 kainate receptor, potentiates glutamate-evoked currents of GluK2a 21-fold at 200 uM (EC50=79 uM).
BPAM344 (100 μM) also potentiated the peak current amplitude of KAR subunits GluK3a (59-fold), GluK2a (15-fold), GluK1b (5-fold), as well as the AMPA receptor subunit GluA1i (5-fold).
BPAM344 stabilizes GluK2 in the closed state in the absence of an agonist or in the presence of DNQX.
