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Chemical Structure : BPAM344
CAS No.: 1204572-55-3
Catalog No.: PC-20090Not For Human Use, Lab Use Only.
BPAM344 (BPAM-344) is a positive allosteric modulator of GluK2 kainate receptor, potentiates glutamate-evoked currents of GluK2a 21-fold at 200 uM (EC50=79 uM).
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| 25 mg | $228 | In stock | |
| 50 mg | $398 | In stock | |
| 100 mg | $688 | In stock | |
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BPAM344 (BPAM-344) is a positive allosteric modulator of GluK2 kainate receptor, potentiates glutamate-evoked currents of GluK2a 21-fold at 200 uM (EC50=79 uM).
BPAM344 (100 μM) also potentiated the peak current amplitude of KAR subunits GluK3a (59-fold), GluK2a (15-fold), GluK1b (5-fold), as well as the AMPA receptor subunit GluA1i (5-fold).
BPAM344 stabilizes GluK2 in the closed state in the absence of an agonist or in the presence of DNQX.
| M.Wt | 242.27 | |
| Formula | C10H11FN2O2S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
4-cyclopropyl-7-fluoro-3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxide |
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1. Etsè KS, et al. ACS Chem Neurosci. 2021 Jul 21;12(14):2679-2692.
2. Larsen AP, et al. Mol Pharmacol. 2017 Jun;91(6):576-585.
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