Welcome to Shanghai Probechem Biochemicals Co Ltd !Global Supplier of Chemical Probes, Inhibitors & Agonists.
Chemical Structure : BPN-15606
CAS No.: 1914989-49-3
Catalog No.: PC-35198Not For Human Use, Lab Use Only.
BPN-15606 (BPN15606) is a highly potent, orally active γ-secretase modulator (GSM), attenuates the production of Aβ42 by SHSY5Y neuroblastoma cells with IC50 of 7 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $258 | In stock | |
| 10 mg | $398 | In stock | |
| 25 mg | $598 | In stock | |
| 50 mg | Get quote | ||
| 100 mg | Get quote |
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
BPN-15606 (BPN15606) is a highly potent, orally active γ-secretase modulator (GSM), attenuates the production of Aβ42 by SHSY5Y neuroblastoma cells with IC50 of 7 nM.
BPN-15606 does not affect Notch cleavage at 25 uM.
BPN-15606 displays the ability to significantly lower Aβ42 levels in the central nervous system of rats and mice at doses as low as 5-10 mg/kg.
BPN-15606 significantly reduces Aβ neuritic plaque load in an AD transgenic mouse model, and significantly reduces levels of insoluble Aβ42 and pThr181 tau in a three-dimensional human neural cell culture model.
| M.Wt | 418.476 | |
| Formula | C23H23FN6O | |
| Appearance | Solid | |
| Storage |
|
|
| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
(S)-N-(1-(4-fluorophenyl)ethyl)-6-(6-methoxy-5-(4-methyl-1H-imidazol-1-yl)pyridin-2-yl)-4-methylpyridazin-3-amine |
|
1. Wagner SL, et al. J Pharmacol Exp Ther. 2017 Jul;362(1):31-44.
Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright
