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BPN-37440

Chemical Structure : BPN-37440

CAS No.: 3120759-70-5

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BPN-37440 (BPN37440)

Catalog No.: PC-26564Not For Human Use, Lab Use Only.

BPN-37440 is a potent, selective prostaglandin-E2 receptor EP2 antagonist with IC50 of 53 nM, with no activity against DP1, EP4 and IP receptors.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

BPN-37440 is a potent, selective prostaglandin-E2 receptor EP2 antagonist with IC50 of 53 nM, with no activity against DP1, EP4 and IP receptors.
BPN-37440 demonstrates anti-inflammatory actions in the BV2-hEP2 cellular model, and exhibits suitable in vitro ADME and in vivo PK properties.
BPN-37440 attenuates microgliosis in the amygdala, cortex, and hippocampus CA3 region 4 days following recovery from status epilepticus (SE).

Physicochemical Properties

M.Wt 346.43
Formula C21H22N4O
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

1,7-Dimethyl-N-(2-(2-methyl-1H-indol-3-yl)ethyl)-1H-pyrrolo[2,3-c]pyridine-2-carboxamide

References

1. Ganesh T, et al. J Med Chem. 2026 Apr 15. doi: 10.1021/acs.jmedchem.6c00172.

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